about 131 km, 1 hour + 20 min

This city is located on the western interior of Sicily. It lies in an area of rolling hills with small villages and towns, crossed by the river Salso. Caltanissetta is the hub of public transport in the area. Caltanissetta is also the site of a longwave transmitter (shutdown in 2002) and shortwave transmitter. The mast used for the longwave transmitter may be the tallest structure in Italy.

Caltanissetta's origins can be traced back to 406 BC, when admiral Nicia of Hamilcar's siege force from Carthage established a fort at the site, later called Castra Nicia (Fort Nicia).

In 1406 Caltanissetta became a fief of the Moncada family of Paternò, and subsequently decayed deeply. In 1539 the construction of the Cathedral was started and in1566 a notable bridge was built over the Salso River. In this period the city began to expand outside the walls, and new quarters (Santa Flavia, San Rocco degli Zingari and San Francesco) were created.